(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone, a homoisoflavonoid, has antiangiogenic activity against human retinal microvascular endothelial cells.

Product information

CAS Number: 849727-88-4

Molecular Weight: 286.28

Formula: C16H14O5

Chemical Name: (3R)-5,7-dihydroxy-3-[(4-hydroxyphenyl)methyl]-3,4-dihydro-2H-1-benzopyran-4-one

Smiles: OC1C=C(O)C2C(=O)[C@H](CC3C=CC(O)=CC=3)COC=2C=1

InChiKey: FIASLUPJXGTCKM-SNVBAGLBSA-N

InChi: InChI=1S/C16H14O5/c17-11-3-1-9(2-4-11)5-10-8-21-14-7-12(18)6-13(19)15(14)16(10)20/h1-4,6-7,10,17-19H,5,8H2/t10-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone has an GI50 value of 35.8 µM on proliferation of human retinal microvascular endothelial cells (HRECs). (R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone (10 µM, 30 µM, and 100 µM; 8 hours) significantly decreases HRECs overall tubule formation and in a dose-dependent manner.

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