Glucocorticoid Receptor Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB10977-50, MB10977-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: P06537

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ICC/IF

All Applications: WB: 1/500-1/1000 IF: 1/50-1/200

Background: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay . Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 87 kDa; Observed MW: 94,91 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Glucocorticoid Receptor in rat skeletal muscle lysates using Glucocorticoid Receptor antibody., Western blot analysis of Glucocorticoid Receptor in K562, 3T3, Hela lysates using Glucocorticoid Receptor antibody., Immunocytochemistry analysis of Glucocorticoid Receptor in Hela using Glucocorticoid Receptor antibody, and DAPI

Alternative Name: GR; GCR; GRL; GCCR; GCRST

Immunogen: Recombinant protein of mouse Glucocorticoid Receptor

Conjugate: Unconjugated

Modification: Unmodified