Dot1L-IN-6 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.19 nM.

Product information

CAS Number: 2565705-01-1

Molecular Weight: 606.99

Formula: C25H21ClF2N6O6S

Chemical Name: N1-[(S)-(3-chloropyridin-2-yl)(2,2-difluoro-2H-1,3-benzodioxol-4-yl)methyl]-N2-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methanesulfonylbenzene-1,2-diamine

Smiles: CS(=O)(=O)C1=CC(NC2N=C(N=C(N=2)OC)OC)=C(C=C1)N[C@H](C1=NC=CC=C1Cl)C1=CC=CC2OC(F)(F)OC=21

InChiKey: ZKUCSIBYPOHTCH-IBGZPJMESA-N

InChi: InChI=1S/C25H21ClF2N6O6S/c1-37-23-32-22(33-24(34-23)38-2)31-17-12-13(41(3,35)36)9-10-16(17)30-19(20-15(26)7-5-11-29-20)14-6-4-8-18-21(14)40-25(27,28)39-18/h4-12,19,30H,1-3H3,(H,31,32,33,34)/t19-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Dot1L-IN-6 (Compound 9) is tested in cellular assays to assess the ability to inhibit the dimethylation of H3K79 in HeLa cells (ED50 H3K79me2 Elisa=12 nM) and HOXA9 gene expression in Molm-13 cells (ED50 HOXA9 RGA=170 nM).

In Vivo:

Dot1L-IN-6 (Compound 9) shows an excellent blood exposure after a single dose (100 mg/kg).

Products are for research use only. Not for human use.